Ribonuclease activity and substrate preference of human eosinophil cationic protein (ECP)
نویسندگان
چکیده
منابع مشابه
Eosinophil cationic protein (ECP) is processed during secretion.
The eosinophil granulocyte is an inflammatory cell involved in allergic diseases such as asthma and rhinitis. Eosinophil cationic protein (ECP) is a basic and potentially cytotoxic granule protein that is released from the eosinophil upon activation. The aim was to study secretion of molecular variants of ECP from blood eosinophils with the hypothesis that the stored noncytotoxic ECP is altered...
متن کاملHuman eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity
We have isolated a 725-bp full-length cDNA clone for the human eosinophil cationic protein (ECP). ECP is a small, basic protein found in the matrix of the eosinophil's large specific granule that has cytotoxic, helminthotoxic, and ribonuclease activity, and is a member of the ribonuclease multigene family. The cDNA sequence shows 89% sequence identity with that reported for the related granule ...
متن کاملProcessed during Secretion Eosinophil Cationic Protein (ECP) Is
The eosinophil granulocyte is an inflammatory cell involved in allergic diseases such as asthma and rhinitis. Eosinophil cationic protein (ECP) is a basic and potentially cytotoxic granule protein that is released from the eosinophil upon activation. The aim was to study secretion of molecular variants of ECP from blood eosinophils with the hypothesis that the stored noncytotoxic ECP is altered...
متن کاملUsefulness of serum eosinophil cationic protein (ECP) in predicting relapse of Churg and Strauss vasculitis.
Sirs, Eosinophil cationic protein (ECP), a cytotoxic granule protein of eosinophils known to play a major role in defence against parasites (1), has been shown to increase in various disorders (2-6) including acute flares of Churg and Strauss syndrome (CSS) (7, 8). We report a case of CSS with elevation of serum ECP months before onset of symptoms on two occasions over 5 1/2 years. High ECP tit...
متن کاملEosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity.
Eosinophil cationic protein (ECP) is one of two RNase A-superfamily ribonucleases found in secretory granules of human eosinophilic leukocytes. Although the physiologic function of eosinophils [and thus of the two eosinophil ribonucleases, ECP and eosinophil-derived neurotoxin (EDN)] remains controversial, we have recently shown that isolated human eosinophils promote ribonuclease-dependent tox...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1991
ISSN: 0014-5793
DOI: 10.1016/0014-5793(91)80994-e